Challenging breast cancer through novel sulfonamide–pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis.

Authors

Amira Khalil, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, The British University in Egypt (BUE), El-Sherouk City, Cairo, 11837, Egypt.Follow
Nashwa H. Zaher, Drug Radiation Research, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt
Reham MM Elhazek, Drug Radiation Research, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt
Ahmed E. Gouda, Pharmaceutical Research Department, Nawah Scientific, Cairo, Egypt
Marwa G. Elgazzar, Drug Radiation Research, National Center for Radiation Research & Technology (NCRRT), Egyptian Atomic Energy Authority, Cairo, Egypt

Document Type

Article

Publication Date

Winter 2-10-2023

Abstract

Background: Among the important key modulators of the tumor microenvironment and hypoxia is a family of enzymes named carbonic anhydrases. Herein, 11 novel sulfonamide–pyridine hybrids (2–12) were designed, synthesized and biologically evaluated for their potential use in targeting breast cancer. Methods & results: The para chloro derivative 7 reported the highest cytotoxic activity against the three breast cancer cell lines used. In addition, compound 7 was found to induce cell cycle arrest and autophagy as well as delaying wound healing. The IC50 of compound 7 against carbonic anhydrase IX was 253 ± 12 nM using dorzolamide HCl as control. Conclusion: This study encourages us to expand the designed library, where more sulfonamide derivatives would be synthesized and studied for their structure–activity relationships.

Recommended Citation

Khalil, Amira; Zaher, Nashwa H.; Elhazek, Reham MM; Gouda, Ahmed E.; and Elgazzar, Marwa G., "Challenging breast cancer through novel sulfonamide–pyridine hybrids: design, synthesis, carbonic anhydrase IX inhibition and induction of apoptosis." (2023). Pharmacy. 607.
https://buescholar.bue.edu.eg/pharmacy/607