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This paper aims to develop a framework to achieve sustainability by overcoming the challenges of the construction supply chain (CCSC) during the design process. To achieve this, two approaches, namely theoretical and practical, were used to accomplish four objectives. For the theoretical approach, based on literature review and case studies, the objective used was to identify, classify and validate the challenges that the construction supply chain (CSC) encounter. For the practical approach, a survey questionnaire was employed to quantify the CCSC and investigate the perception of architectural design firms (ADFs) in Egypt towards achieving sustainability by overcoming the CCSC during the design process. Based on the results, the research developed a framework to overcome the CCSC as an approach towards achieving sustainability in construction projects during the design process. The research identified and validated 20 challenges that the CSC encounter towards achieving sustainability during the design process. These challenges were classified under four categories, namely (1) design and technical process; (2) coordination, information flow and accuracy; (3) material specification, technology, supplier rework and whole life cycle cost; and (4) skills gap of the qualified architects and design managers and non-compliance to building codes, regulations, laws and standards. In addition, a survey questionnaire was employed to rank these challenges according to their importance on 1–5 Likert scale using the measure of central tendency and dispersion and relative importance index (RII).