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Construction and demolition waste (CDW) is a critical challenge facing the construction industry. It leads to deterioration of the triple bottom line of sustainability. Unfortunately, the CDW management research in Egypt lacks studies investigating (1) the variations in CDW generation (CDWG) among different types of construction projects, and (2) the factors affecting CDW reduction (CDWR). Based on a benchmarking approach, this research (1) quantifies CDW in terms of generation rates and costs among different construction project types in Egypt, and (2) investigates the relationship between CDWG and different adopted CDWR factors. Using structured interviews, a comparative case study was conducted to investigate industrial, residential, commercial, and infrastructure projects. Analysis of results demonstrated that CDWG rates and costs differ from one project type to another due to the project’s nature, size, and complexity on the one hand, and the applied CDWR factors such as waste-efficient practices, awareness, culture & behaviour, and legislation on the other hand. On average among the four project types, it was found that ‘‘timber”, ‘‘sand”, and ‘‘bricks/blocks” are the most wasteful materials. It was also found that ‘‘practices” and ‘‘legislation” are the least applied CDWR factors on average among the four project types, which need to be better applied for better CDWR results.