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In this article, we examine the mechanism of cobalt and tantalum nanoparticles through a hybrid fluid model. The nanofluid is propagating through an anisotropically tapered artery with three different configurations; converging, diverging and non-tapered. To examine the rheology of the blood we have incorporated a Williamson fluid model which reveals both Newtonian and non-Newtonian effects. Mathematical and physical formulations are derived using the Lubrication approach for continuity, momentum and energy equations. The impact of magnetic field, porosity and viscous dissipation are also taken into the proposed formulation. A perturbation approach is used to determine the solutions of the formulated nonlinear coupled equations. The physical behavior of all the leading parameters are discussed for velocity, temperature, impedance and streamlines profile. The current analysis has the intention to be used in therapeutic treatments of anemia because cobalt promotes the production of red blood cells since it is a component of vitamin B12, this is in addition to having tantalum that is used in the bone implants and in the iodinated agents for blood imaging due to its long circulation time.