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In the modern knowledge-based global economy, universities are being required to operate more entrepreneurially, commercialising the results of their research and spinning out new knowledge-based enterprises. In this article, the third in the series (El Hadidi and Kirby, 2015a and b), case studies are presented of activities in 3 Egyptian universities in order to demonstrate what is being done and the challenges Egyptian universities are facing when attempting to collaborate with industry and contribute to the innovation process. The results reveal that the initiatives are often the result of external influences and are not embedded within the core strategic planning activity of the institutions in which they are located. Accordingly they often have difficulty surviving after the initial project funding is ended, not least as the important partnership links with industry remain largely underdeveloped. The article considers the implications of the findings for policy formulation and argues for a coherent strategy that embeds the “third mission” within the core activities of each institution and facilitates university-industry collaboration.