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Novel Schiff bases were prepared as the condensation product of reaction of 2- hydroxybenzaldehyde and ambroxol drug (H2L1) and the second one from the reaction of 2-quinoline carbaldehyde with ambroxol (HL2). The synthesized Schiff basses were acted as a tridentate ligand for the preparation of new complexes through reaction with the metal ions of Cd(II) and Sn(II). The newly prepared Schiff bases and their metal complexes were characterized using some physicochemical techniques including elemental analysis, FT-IR, UV–Vis, mass spectrometry, conducti-metric measurements as well as thermal analyses (TGA/DTG),. On the basis of these studies, an octahedral geometry for both Cd(II) and Sn(II) complexes has been suggested. The antimicrobial activity against some species of bacteria and fungi organisms was employed to the two Schiff bases and their complexes. The results showed that the Cd(II) complex recorded the highest antimicrobial activity.