Potential Role of Calprotectin and Pentraxin-3 As Biomarkers Of Periodontal Disease.

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Background: Periodontal diseases are characterized by a complex set of biologic interactions between a diverse and dynamic microbial ecosystem and the host’s responsive immune and inflammatory machinery. This study was designed to evaluate salivary levels of calprotectin and PTX3 in patients suffering from chronic and aggressive periodontitis to assess their potential role as biomarkers of periodontal disease. Materials and methods: This study was performed on a total of 90 patients divided into 3 groups; 30 patients with chronic periodontitis, 30 patients with aggressive periodontitis and 30 control individuals. The levels of calprotectin and PTX3 were measured in the saliva of all patients and controls by ELISA Kits. Result: AgP group showed the statistically significantly highest mean calprotectin and PTX3 level. CP group showed statistically significantly lower mean level than AgP group. Control group showed the statistically significantly lowest mean calprotectin and PTX3 level of all groups. Conclusions: based on our work we can advocate that both PTX3 and calprotectin could be used as preferred biomarkers in periodontal disease diagnosis.

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