Local And Systemic Level Of Adipokines As Markers Of Inflammation In Periodontitis And Type 2 Diabetes Mellitus After Periodontal Therapy.

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Objective Periodontal disease and diabetes mellitus are common disorders connected mainly by inflammation. While exploring and analyzing the several pathways linking diabetes and periodontitis, adipokines were prominent candidates amongst the biochemical parameters that could elucidate this interrelation. Therefore, the present investigation was conducted to evaluate the effect of nonsurgical periodontal treatment on the glycemic control of well‑controlled patients with type 2 diabetes mellitus (T2DM) and chronic periodontitis (CP), as well as on the serum and GCF levels of visfatin, chemerin and adiponectin in systemically healthy subjects with CP, controlled T2DM patients with CP. Patients and methods Serum and GCF samples were collected at baseline and 3 months after therapy to evaluate levels of visfatin, chemerin and adiponectin using enzyme linked immunosorbent assay in all study groups. Group I: 15 healthy individuals. Group II: 30 CP patients. Group III: 30 periodontitis patients with T2DM. Results Significant reduction in serum and GCF levels of both chemerin and visfatin were recorded 3 months after therapy in periodontitis groups. On the contrary, significant elevation of serum and GCF levels of adiponectin were found. There was a direct positive correlation between percent change in serum glycosylated haemoglobin A1c level and serum visfatin and chemerin level and a negative correlation with serum adiponectin level. Conclusion This study demonstrates that serum and GCF levels of chemerin, visfatin and adiponectin play a crucial role in the pathogenesis of periodontitis and diabetes and reinforce the positive effect of periodontal therapy on the glycemic control.

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