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Aim: Compare efficacy of Dual Rinse HEDP with sodium hypochlorite to sodium hypochlorite in combination with a finishing rinse with 17% EDTA solution to remove the smear layer.

Materials and methods: Sixteen human maxillary single-rooted, single canalled sound premolars were used. Specimens were distributed into 2 groups and labeled according to irrigation protocol used. Each group consisted of 8 specimens: Group 1 50% NaOCl followed by 17% EDTA. Group 2 The Dual Rinse® HEDP mixed with 50% NaOCl. Roots were prepared for SEM appraisal. The smear layer was assessed and scored. Energy-dispersive X-ray analysis was used to analyze the inorganic chemical structure of the treated dentin of the two tested groups. Data were tabulated and statistically analyzed.Kruskal-Wallis test tailed by Mann-Whitney test compared mean scores between irrigant solutions and root regions groups. Chi-square test compared the frequency distribution of scores between different groups.

Results: Smear layer was reduced with The Dual Rinse® HEDP group. Groups exhibited a statistically significant difference in mean scores within apical region and no statistically significant difference within coronal and middle regions. Groups showed a statistically significant difference in frequency distribution of scores within coronal and apical regions. A statistically significant difference in scores frequency existed in between the three root regions within NaOCl+EDTA group While no difference was present in between the different regions within Dual Rinse® HEPD group. Energy- dispersive X-ray analysis showed lower peaks of calcium in the Dual Rinse® HEDP.

Conclusion: The Dual Rinse® HEDP can be used as one step irrigant.