Document Type


Publication Date

Spring 10-2017


Salivary glands are affected by immunosuppressive drugs, like Cyclosporine-A (CsA) which plays a major role in transplant medicine. Thus, this work aimed to study the possible therapeutic effect of purslane on CsA induced salivary gland alterations.

Materials & Methods: 30 adult male albino rats were equally divided into 3 groups: control group ] received a vehicle, CsA group received 20 mg/kg/day of CsA, and combination group received CsA and 400mg/kg/day of purslane. Three weeks later rats were sacrified then the submandibular salivary glands were prepared for histological andKi67 immunohistochemical analysis, then the studied groups were statistically evaluated.

Results: Histological examination of the control group revealed the normal histology, while in the CsA group; the acinar and ductal cells showed numerous vacuolizations and reduced cytoplasmic basophilia associated with areas of degeneration. Immunohistochemical examination of the Ki-67 showed a few number of positive nuclei in the control other hand, the combination group displayed marked reduction in Ki-67 immunoreactivity than that in the CsA group.

Conclusions: administration of purslane to CsA treated rats resulted in an obvious improvement in the histological picture of the submandibular salivary glands and also it had a potent antiproliferative effect. Thus, purslane could be beneficial in ameliorating CsA-induced salivary gland alterations.