Document Type

Article

Publication Date

2025

Abstract

Purpose: The present study evaluated the sensitivity and specificity of important proteomic salivary biomarkers; IL-6, IL-8, and sCD44 in the early detection of oral cancer, and any poss associations with risk factors of oral cancer in an Egyptian population Methods: The present investigation was conducted on 100 individuals; 25 healthy controls, 25 patients having oral potentially malignant disorders (OPMDs) with dysplasia; 25 patients having OPMDs without dysplasia, and 25 oral cancer patients. Demographic data modified gingival index, oral hygiene level, and salivary levels of the biomarkers were assessed. Results: Salivary levels of IL-6, IL-8, and sCD44 progressively increased with increased di severity. Salivary IL-8 and IL-6 levels possess a discriminating potential from normal ti through different degrees of dysplasia to oral cancer, sCD44 levels had a discriminating power between normal and dysplastic tissues with high sensitivity and specificity. positive correlation was found between the three biomarkers and the grade of oral squamous cell carcinoma (OSCC) and with different risk facto Conclusion: This is the first study that evaluated multiple salivary proteomic biomarkers in the Egyptian population, and the results validate the ability of IL-6, IL-8, and sCD44 used as sensitive diagnostic and prognostic biomarkers for screening and early detection of oral cancer

Comments

ARTICLE HIGHLIGHTS • Salivary IL-8 and IL-6 levels possess a discriminating potential from normal tissue thr different degrees of dysplasia to oral cancer. • sCD44 levels have a discriminating power between normal and dysplastic tissues with high sensitivity and specificity. • There is a positive correlation between the three biomarkers and different oral cancer risk factors. • Assessment of salivary levels of these proteomic biomarkers constitutes a simple, noninvasive, point-of-care diagnostic tool. • Salivary proteomic biomarkers may help identify individuals at high risk for oral cancer, facilitate early detection of oral cancer and malignant transformation in OPMDs

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