The Effect of Platelet-Rich Fibrin on Bone Defects Repair in Experimental Animals: A Mini-Review

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Bone is a unique hard form of connective tissue as a result of its heavily calcified extra cellular components. Platelet-Rich Fibrin (PRF), a second generation platelet concentrate, becomes a powerful bioscaffold with an integrated reservoir of growth factors for tissue regeneration. Several studies showed that PRF has positive effect on soft and hard tissue regeneration. Here we present recent literature exploring the osteogenic effects of PRF alone or combined with other materials on bone defects healing in various animal models.