Antioxidant flavonol glycosides from Schinus molle

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Chromatographic separation of aqueous MeOH extract of the leaves of Schinus molle L. has yielded two new acylated quercetin glycosides, named isoquercitrin 6″-O-p-hydroxybenzoate (12) and 2″-O-α-L-rhamnopyranosyl- hyperin 6″-O-gallate (13), together with 12 known polyphenolic metabolites for the first time from this species, namely gallic acid (1), methyl gallate (2), chlorogenic acid (3), 2″-α-L-rhamnopyranosyl-hyperin (4), quercetin 3-O-β-D-neohesperidoside (5), miquelianin (6), quercetin 3-O-β-D-galacturonopyranoside (7), isoquercitrin (8), hyperin (9), isoquercitrin 6″-gallate (10), hyperin 6″-O-gallate (11) and (+)-catechin (14). Their structures were established on the basis of chromatographic properties, chemical, spectroscopic (UV, 1H, 13C NMR) and ESI-MS (positive and negative modes) analyses. Compounds 4-9 and 11 exhibited moderate to strong radical scavenging properties on lipid peroxidation, hydroxyl radical and superoxide anion generations with the highest activities shown by 6 and 7 in comparison with that of quercetin as a positive control in vitro. Copyright © 2006 John Wiley & Sons, Ltd.

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