Does tissue polypeptide-specific antigen (TPS) relate to tissue polypeptide antigen (TPA) in Ehrlich ascites carcinoma (EAC)-bearing mice?

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In the last few years IPS (specific TPA) has been evolved as a tumor marker defined by a monoclonal antibody (M3) against one of the specific epitopes of the Tissue Polypeptide Antigen (TPA) molecule. There is a controversy as to whether TPS release relates to proliferation of tumor cells or not. The present work investigates the relation between TPS, TPA, cytokeratins 8,18 (TPAcyk) and S-phase status in the ascitic fluid of EAC-bearing mice. The study reveals negative expression of TPS by EAC cells while the correlation between TPA and TPACYK is r = 0.205. TPA calculated in terms of U/l shows a good positive correlation with the S-phase while the opposite is true for TPA expressed in terms of TPA as units in the whole ascitic fluid.

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