Isolation of hypotensive flavonoids from chenopodium species growing in egypt
TLC investigation of the flavonoid fraction of Chenopodium murale L. revealed the presence of three components. The major was identified as kaempferol-3,7-dirhamnoside 1 (kaempferitrin; lespedin) through its MP, UV, IR, MS and NMR (H-H COSY and H-C. HECTOR) spectra. Testing the effect of compound 1 as well as the total flavonoid mixture on the rabbit cardiovascular system, showed dose-related hypotension and bradycardia. Compound 1 also produced a dose-related hypotension in genetically prone hypertensive rats. Compound 1 did not block α1 or β1-adrenoceptors when tested using isolated guinea-pig aortic strip and atria, respectively. Quantification of 1 in C. ambrosoides, C. murale, C. ficifolium and C. album revealed that the former contains the highest level.
Gohar, Ahmed A. and Elmazar, Mohamed M., "Isolation of hypotensive flavonoids from chenopodium species growing in egypt" (1997). Pharmacy. 235.