Rosemary and neem: an insight into their combined anti-dandruff and anti-hair loss efficacy

Document Type

Article

Publication Date

Spring 4-2-2024

Abstract

Dandruf, a common scalp disorder characterized by faking dead skin, is often treated with conventional topical products. However, limitations exist due to potential side efects and high costs. Therefore, searching for natural, cost-efective solutions for dandruf and hair loss is crucial. Rosemary herb and neem tree, both cultivated in Egypt, possess well-documented anti-infammator properties derived from their rich phenolic phytoconstituents. This study formulated a standardized combined extract of rosemary and neem (RN-E 2:1) into hair gel and leave-in tonic formats. Thi extract demonstrated superior efcacy against Malassezia furfur (a causative agent of dandruf) and Trichophyton rubrum (associated with scalp disorders) compared to the conventional antifungal agent, ketoconazole. The combined extract (RN-E 2:1) also exhibited potent anti-infammatory activity Additionally, the suppression of iNOS expression is considered concentration-dependent. Quality control verifed formulation stability, and ex-vivo studies confrmed efective ingredient penetration into the epidermis, the primary site of fungal presence. Remarkably, both formulations outperformed the standard treatment, minoxidil in hair growth trials. These fndings highlight the potential of natural extracts for scalp and hair health

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