General procedure for the synthesis of dinucleoside polyphosphates
Dinucleoside 5′,5′-polyphosphates (N(p) nN) play important roles in biological processes and have been developed into drugs. However, their synthesis still remains a challenge. Here we report a rapid and general approach to the synthesis of dinucleoside 5′,5′- polyphosphates by coupling highly reactive nucleoside 5′-monophosphate-N- methylimidazolium salts donors with nucleoside 5′-mono-, -di-, and -triphosphate acceptors. © 2011 American Chemical Society.
Mohamady, Samy and Taylor, Scott D., "General procedure for the synthesis of dinucleoside polyphosphates" (2011). Pharmacy. 97.