An improved method for the synthesis of nucleoside triphosphate analogues
Nucleoside monophosphates, when activated by trifluoroacetic anhydride and N-methylimidazole, efficiently couple with a variety of electron-deficient diphosphonates in a reproducible and efficient manner (<2 >h, >72% isolated yield). Unlike traditional methods for the preparation of nucleoside 5′-β,γ-methylenetriphosphate analogues, there is no requirement for predrying, or conversion to specific salt forms, of commercially available nucleoside monophosphate starting materials. © 2005 American Chemical Society.
Mohamady, Samy and Jakeman, David L., "An improved method for the synthesis of nucleoside triphosphate analogues" (2005). Pharmacy. 98.