Title

An improved method for the synthesis of nucleoside triphosphate analogues

Document Type

Article

Publication Date

12-9-2005

Abstract

Nucleoside monophosphates, when activated by trifluoroacetic anhydride and N-methylimidazole, efficiently couple with a variety of electron-deficient diphosphonates in a reproducible and efficient manner (<2 >h, >72% isolated yield). Unlike traditional methods for the preparation of nucleoside 5′-β,γ-methylenetriphosphate analogues, there is no requirement for predrying, or conversion to specific salt forms, of commercially available nucleoside monophosphate starting materials. © 2005 American Chemical Society.

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