Immunohistochemicsl Assessment of Epcam Expression in Different Grades of Oral Squamous Cell Carcinoma

Authors

• Safaa Baz, Department of Oral Pathology, Faculty of Dentistry, The British University in EgyptFollow
• Iman Mohamed Helmy, Professor, Department of Oral Pathology, Faculty of Dentistry, Ain Shams University
• Mohamed Hossam Eldin El Mallahy, Professor, Department of Oral Pathology, Faculty of Dentistry, Ain Shams University

Document Type

Article

Publication Date

9-2014

Abstract

Epithelial cell adhesion molecule (EpCAM) is a hemophilic Ca2+ independent adhesion molecule. This study used an immunohistochemical technique (IHC) to examine the expression of EpCAM in thirty-two specimens of OSCC (comprising 13 well-, 9 moderately, and 10 poorly differentiated cases), and 2 specimens of normal oral mucosa, used as control. It was found that the mean area fraction of EpCAM immunopositivity became lower as the grade worsened. A highly statistically significant difference existed between groups (P-value < 0.001). We concluded that EpCAM could help to stratify the different grades of OSCC. In addition, EpCAM could be a biomarker for prediction of prognosis.

Recommended Citation

Baz, Safaa; Helmy, Iman Mohamed; and El Mallahy, Mohamed Hossam Eldin, "Immunohistochemicsl Assessment of Epcam Expression in Different Grades of Oral Squamous Cell Carcinoma" (2014). Dentistry. 506.
https://buescholar.bue.edu.eg/dentistry/506