Torge Hartig, Chair for Multicomponent Materials Department of Materials Science Kiel University 24143 Kiel, GermanyFollow
Asmaa T. Mohamed, Nanotechnology Research Centre (NTRC) The British University in Egypt (BUE)Follow
Nasra F. Abdel Fattah, Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo UniversityFollow
Aydin Gülses, Department of Oral and Maxillofacial Surgery Campus Kiel University Hospital of Schleswig-Holstein 24105 Kiel, GermanyFollow
Tim Tjardts, Chair for Multicomponent Materials Department of Materials Science Kiel University 24143 Kiel, GermanyFollow
Esther Afiba Kangah, Department of Oral and Maxillofacial Surgery Campus Kiel University Hospital of Schleswig-Holstein 24105 Kiel, GermanyFollow
Kwing Pak Gabriel Chan, Chair for Multicomponent Materials Department of Materials Science Kiel University 24143 Kiel, GermanyFollow
Salih Salih Veziroglu, Chair for Multicomponent Materials Department of Materials Science Kiel University 24143 Kiel, GermanyFollow
Yahya Acil, Department of Oral and Maxillofacial Surgery Campus Kiel University Hospital of Schleswig-Holstein 24105 Kiel, GermanyFollow
Oral Cenk Aktas, Chair for Multicomponent Materials Department of Materials Science Kiel University 24143 Kiel, GermanyFollow
Jörg Jörg Wiltfang, Department of Oral and Maxillofacial Surgery Campus Kiel University Hospital of Schleswig-Holstein 24105 Kiel, GermanyFollow
Samah A. Loutfy, Nanotechnology Research Centre (NTRC) The British University in Egypt (BUE), Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo UniversityFollow
Thomas Strunskus, Chair for Multicomponent Materials Department of Materials Science Kiel University 24143 Kiel, GermanyFollow
Franz Faupel, Chair for Multicomponent Materials Department of Materials Science Kiel University 24143 Kiel, GermanyFollow
Amal Amin, Department of polymers and pigments National Research Center NRC,EgyptFollow
Stefan Schröder, Chair for Multicomponent Materials Department of Materials Science Kiel University 24143 Kiel, GermanyFollow

Document Type

Article

Publication Date

Summer 9-25-2023

Abstract

Thin polymer coatings are used to improve the interface between biological species and functional materials. Their interaction is significantly influenced by the functional groups and roughness of the polymer film and prediction of the interaction is thus of great interest. However, for conventional polymer films, this cannot be examined independently because of the interplay of defects, residual solvent molecules, roughness, and functional groups. Solvent-free polymer films prepared by initiated chemical vapor deposition (iCVD) exhibit conformal, defect-free characteristics and enable precise tailoring of the functional groups. This facilitates to isolate the contribution of functional groups on the bio-interface performance. Consequently, in silico studies can enable a prediction of ligand interaction in anti-viral activity for SARS-CoV-2 based on defined polymer and key protein structures. Furthermore, the cell viability of human fibroblasts can be traced back to the functional groups of the repeating units. For human liver cancer cell culture, it turns out that more sophisticated models are needed. The insilico-iCVD approach can enable precise tailoring of complex polymer films optimized for the respective interfaces. In addition, this first big scan of the bio-interface performance of iCVD films enables a solid starting point in areas like anticancer, antiviral, and biocompatibility for future studies.

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