Phytochemical and pharmacological studies on Lactuca sativa seed oil
The seed oil of L. sativa var. longifolia was chemically characterized. GLC revealed that the oil is built-up of oleic (61.5%), stearic (20.4), palmitic (9.7), myristic (2.8), cis-palmitoleic (1.2), behenic (0.5) and lignoseric (0.3) acids. β-Sitosterol and β-amyrin were identified by TLC. The oral LD50 of the oil in mice was found to be 19.8 ml/kg. The oil showed sedative effect in locomotor activity test, potentiation of the hypnotic effect of barbiturates, analgesic effect in acetic acid-induced writhing test and anticonvulsant activity against pentylenetetrazole-induced convulsion. The oil exhibits tolerance to its neurological effects on repeated use for prolonged time.
Said, S. A.; Kashef, H. A.E.; Mazar, M. M.E.; and Salama, O., "Phytochemical and pharmacological studies on Lactuca sativa seed oil" (1996). Pharmacy. 244.