Microbial side-chain degradation of progesterone II. Application of different techniques for progesterone conversion by Fusarium dimerium

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A local isolate of Fusarium dimerium, firstly reported to be able to degrade progesterone side chain to give certain C-19 androgenes derivatives, proved to perform this important conversion more efficiently adopting the cell immobilization technique. Thus, relatively more amounts of Androst - 4 - ene - 3, 17 - dione (AD), Testololactone (TL) (major products) as well as, Testosterone (T), Androsta - 1,4 - diene 3, 17 - dione (ADD) (minor products) were recorded after 72 h using 2% Ca - alginate immobilized fungal cells. Relatively lower bioconversion rates were achieved when the bioconversion process was carried out in top - laboratory fermentor using free cells of the promising fungus.

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