"An improved method for the synthesis of nucleoside triphosphate analog" by Samy Mohamady and David L. Jakeman
 

An improved method for the synthesis of nucleoside triphosphate analogues

Document Type

Article

Publication Date

12-9-2005

Abstract

Nucleoside monophosphates, when activated by trifluoroacetic anhydride and N-methylimidazole, efficiently couple with a variety of electron-deficient diphosphonates in a reproducible and efficient manner (<2 >h, >72% isolated yield). Unlike traditional methods for the preparation of nucleoside 5′-β,γ-methylenetriphosphate analogues, there is no requirement for predrying, or conversion to specific salt forms, of commercially available nucleoside monophosphate starting materials. © 2005 American Chemical Society.

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