Cytotoxicity and Chemical Investigation of the Aerial Parts of Markhamia zanzibarica (Bojer Ex Dc.) K. Schum. (Bignoniaceae)

Authors

Dina M. El-Kersh, The British University in EgyptFollow
Riham S. El Dine, Faculty of Pharmacy Cairo University
Dina R. Abou-Hussein, Faculty of Pharmacy Cairo University
Fatma S. El-Sakhawy, Faculty of Pharmacy Cairo University
Mohamed M. Elmazar, The British University in EgyptFollow

Document Type

Article

Publication Date

2016

Abstract

The ethanolic extract of the aerial parts of Markhamia zanzibarica (Bignoniaceae) was tested for its cytotoxic activity against human cervical adenocarcinoma cell line (HeLa). It showed a potent effect with an IC50 of 9.68 μg/ml compared to Doxorubicin (7.28 μg/ml). The fractions obtained from the successive partitioning of the total extract, were tested against the same cell line; the results revealed that n-hexane extract was the most potent 9.23 μg/ml, followed by ethyl acetate, butanol and chloroform fractions with IC50 of 21.2, 22.4 and 49.6 μg/ml, respectively. Column chromatography led to the isolation of oleanolic acid (1), ursolic acid (2) and luteolin (3). The structures of the isolated compounds were elucidated using spectroscopic techniques.

Recommended Citation

El-Kersh, Dina M.; El Dine, Riham S.; Abou-Hussein, Dina R.; El-Sakhawy, Fatma S.; and Elmazar, Mohamed M., "Cytotoxicity and Chemical Investigation of the Aerial Parts of Markhamia zanzibarica (Bojer Ex Dc.) K. Schum. (Bignoniaceae)" (2016). Pharmacy. 494.
https://buescholar.bue.edu.eg/pharmacy/494