"Square wave voltammetric determination of rasagiline mesylate on hangi" by Ibrahim H.I. Habib, Mohamed Rizk et al.
 

Square wave voltammetric determination of rasagiline mesylate on hanging mercury drop electrode and its application in dosage form and biological fluids

Document Type

Article

Publication Date

6-1-2016

Abstract

© 2016 The Authors. A new square wave voltammetric (SWV) method has been developed and validated for the determination of Rasagiline mesylate in bulk, dosage form and human plasma due to a cathodic behaviour of its acetylene group at Hanging Mercury Drop Electrode (HMDE). Many facts such as different supporting electrolytes, scan rate, pulse amplitude, accumulation time and accumulation potential were studied. A good linearity was obtained over a concentration range of (2.8 x10-8 to1.4 x10-7mol L-1) with 99.78% as mean recovery and 1.09%, as the relative standard deviation and limits of detection and quantification were found to be (2.7 x10-9 and 9.24 x1 0-9mol L-1), respectively. The accuracy and precision of the method were within acceptable limits. The method was applied for determining the active ingredients in its tablets with % recoveries ± relative standard deviation of 95.46 ± 3.7 6 and in spiked human plasma with 94.3 ± 2.8 9%, respectively.

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