"COGNITIVE PROCESSING THERAPY VERSUS MEDICATION FOR THE TREATMENT OF CO" by Amani S. Elbarazi, Osama Badary et al.
 

COGNITIVE PROCESSING THERAPY VERSUS MEDICATION FOR THE TREATMENT OF COMORBID SUBSTANCE USE DISORDER AND POST-TRAUMATIC STRESS DISORDER IN EGYPTIAN PATIENTS (RANDOMIZED CLINICAL TRIAL)

Document Type

Article

Publication Date

Fall 9-1-2022

Abstract

Earlier research has established that posttraumatic stress disorder (PTSD) and substance use disorder (SUD) frequently coexist. Aims: Cognitive Processing Therapy was compared to Sertraline and a placebo in an RCT for treating patients with comorbid SUD and PTSD. Methods: 150 patients with SUD and PTSD were interviewed by clinicians and asked to fill out the Clinician-Administered PTSD Scale (CAPS-5), Posttraumatic Stress Disorder Checklist (PCL-5), Beck Depression Inventory (BDI-II), Timeline Follow Back Interview (TLFB), and Brief Addiction Monitor (BAM). Patients were randomly assigned to the following conditions: CPT (n=50), Sertraline (n=50), or Placebo (n=50). Pretreatment, posttreatment, six and, twelve-month follow-up assessments were conducted. Results: When compared to the sertraline group, CPT resulted in much higher reductions in CAPS scores at posttreatment assessment (d=0.93, p < .000). When compared to the control group, CPT considerably reduced PTSD symptoms (the effect size, d=1.9, p < .000). Sertraline resulted in many significant decreases in CAPS when compared to control groups (the effect size, d=1.11, p < .000). At posttreatment, SUD and depression severity were significantly reduced in both CPT and Sertraline groups. After six and twelve months of follow-up, these differences persisted. Conclusion: Comparatively to the control group, CPT and Sertraline significantly decreased PTSD, SUD, and depression.

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