Novel Repurposed Nano-Facial sheet masks For Dermatological Disease

Document Type

Conference Proceeding

Publication Date

12-2022

Abstract

Drug repurposing has become one of the most valuable strategies that works on overcoming the tedious process of long-term drug discovery. Moreover, nano-drug delivery systems technology has proven its crucial role in maximizing the benefits of repurposed drugs via its role in customizing the release pattern of the repurposed drugs. Drug repurposing also has the ability to target new sites of action for the repurposed drugs and disposition of the repurposed drugs in new routs of administrations. Spironolactone is a repurposed drug with many off label (repurposed) uses for many dermatological diseases. In this study, spironolactone was formulated into polymeric electrospun nanofibrous sheet masks to maximize its activity, negate its systemic side effects and target skin diseases. Electrospinning method was used in the preparation process. Characterization of the prepared nanofibrous sheet masks were done, and the obtained results proved that the fiber diameters in the nano-range with no beads. It also showed that there was compatibility between the whole ingredients of nanofibrous sheet mask, in addition to successful incorporation between the drug and nanofibrous mats. The release pattern was also tested and an improvement in the amount released was obvious compared to pure drug. An animal Ex-vivo test was also completed and has proven the successful delivery of topical spironolactone using nanofibrous sheet masks.

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