One flask synthesis of 2′,3′-cyclic nucleoside monophosphates from unprotected nucleosides using activated cyclic trimetaphosphate

Document Type

Article

Publication Date

1-1-2016

Abstract

© 2016 Elsevier Ltd The 2′,3′-cyclic nucleoside monophosphates (2′,3′-cNMPs) of adenosine, guanosine, cytidine, and uridine were prepared in good yield in a one pot reaction from unprotected ribonucleosides and activated trimetaphosphate in the presence of N-methylimidazole, 4-nitroimidazole and MgCl2.

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