"Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphat" by Samy Mohamady and Scott D. Taylor
 

Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates via activation of cyclic trimetaphosphate

Document Type

Article

Publication Date

6-26-2013

Abstract

A procedure for the synthesis of dinucleoside 5′-pentaphosphates (Np5N) and nucleoside 5′-tetraphosphates (Np4) is described. The procedure relies on the activation of cyclic trimetaphosphate followed by a reaction with a nucleoside 5′-monophosphate (NMP) to give intermediates of type 3. Reaction of 3 with water or an NMP gives the desired products in yields ranging from 77 to 86%. © 2013 American Chemical Society.

This document is currently not available here.

Share

COinS