Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates via activation of cyclic trimetaphosphate

Document Type

Article

Publication Date

6-26-2013

Abstract

A procedure for the synthesis of dinucleoside 5′-pentaphosphates (Np5N) and nucleoside 5′-tetraphosphates (Np4) is described. The procedure relies on the activation of cyclic trimetaphosphate followed by a reaction with a nucleoside 5′-monophosphate (NMP) to give intermediates of type 3. Reaction of 3 with water or an NMP gives the desired products in yields ranging from 77 to 86%. © 2013 American Chemical Society.

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