Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates via activation of cyclic trimetaphosphate
A procedure for the synthesis of dinucleoside 5′-pentaphosphates (Np5N) and nucleoside 5′-tetraphosphates (Np4) is described. The procedure relies on the activation of cyclic trimetaphosphate followed by a reaction with a nucleoside 5′-monophosphate (NMP) to give intermediates of type 3. Reaction of 3 with water or an NMP gives the desired products in yields ranging from 77 to 86%. © 2013 American Chemical Society.
Mohamady, Samy and Taylor, Scott D., "Synthesis of nucleoside tetraphosphates and dinucleoside pentaphosphates via activation of cyclic trimetaphosphate" (2013). Pharmacy. 93.