Smart nanovesicles for drug delivery

Document Type

Book

Publication Date

Winter 1-1-2022

Comments

he fast and continuous progress in diagnosis, treatment, and follow-up of different diseases and disorders based on the nanotechnology platform opened the door for new fields known as nanomedicine and nanostructures for use in different fields as targeted delivery. Nanocarriers are designed and fabricated from different materials such as metals, polymers, nanogels, surfactants, and lipids. Nanocarriers as smart drug delivery systems have more merits than conventional ones as they facilitate drug internalization into cells, improve pharmacokinetics and the drug release profile of the therapeutic agents, and minimize toxic effects, increasing the retention time in the circulation and enhancing the overall therapeutic efficacy. Smart nanocarriers are usually programmed to release the therapeutic agents at a specific rate and effective amounts at the targeted site. Vesicular delivery systems having a hollow interior core surrounded by a bilayer membrane have gained popularity due to their capability in amending the distribution profiles of the encapsulated therapeutic agents and controlling their release in an optimum way to maximize therapeutic efficacy. Vesicular structures also have the ability to increase the absorption rate and accommodate and carry larger amounts of therapeutic agents whether hydrophobic or hydrophilic in nature. Surface modification through conjugation with the functional group could make the vesicular nanostructures smarter and able to target specific sites and deliver their contents efficiently to the interior of the targeted cells. Smart nanovesicles should also be stable physically and chemically, biocompatible, biodegradable, easy to be handled and stored, safe, and economic

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