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Submissions from 2018

Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis, Amal Bouzid, Ibtihel Smeti, Leila Dhouib, Magali Roche, Imen Achour, Aida Khalfallah, Abdullah Ahmed Gibriel, Ilhem Charfeddine, Hammadi Ayadi, Joel Lachuer, Abdelmonem Ghorbel, Christine Petit, and Saber Masmoudi

Obestatin can potentially differentiate Wharton’s jelly mesenchymal stem cells into insulin-producing cells, Rana K. El-Asfar, Mohamed M. Kamal, Rania S. Abd EL-Razek, Ebtehal EL-Demerdash, and Hala O. El-Mesallamy

Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: Formulation and clinical study, Shaimaa El-Housiny, Maii Atef Shams Eldeen, Yasmina Ahmed El-Attar, Hoda A. Salem, Dalia Attia, Ehab R. Bendas, and Mohamed A. El-Nabarawi

Immuno-analytical approach and its application for cardiac disease marker detection, Reham F. El-Kased

Antimicrobial resistance, biofilm formation, and phylogenetic grouping of uropathogenic Escherichia coli isolates in Egypt: The role of efflux pump-mediated resistance, Wesam Elsayed Gawad, Omneya Mohamed Helmy, Wael Mostafa Tawakkol, and Abdel Gawad M. Hashem

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Down-expression of P2RX2, KCNQ5, ERBB3 and SOCS3 through DNA hypermethylation in elderly women with presbycusis, Abdullah A.Y. Gibriel, A Bouzid, I Smeti, L Dhouib, M Roche, I Achour, A Khalfallah, I Charfeddine, H Ayadi, J Lachuer, A Ghorbel, C Petit, and S Masmoudi

Moxifloxacin hydrochloride electrochemical detection based on newly designed molecularly imprinted polymer, Mennatallah A. Hammam, Hebatallah Wagdy, and Rasha M. El Nashar

A cytotoxic flavonol glycoside from Melaleuca leucadendra leaves extract with immunostimulant activity, A. N. Hashim, Noha Swilam, E. S. Moustafa, S. M. Bakry, R. M. Labib, H. H. Barakat, A. B. Singab, M. W. Linscheid, and M. A. Nawwar

Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model, Shireen A. Hedya, Marwa M. Safar, and Ashraf K. Bahgat

Molecular docking and semi-empirical quantum studies on cholesterol with cyclodextrins, Boubaker Hosouna, Ashraf A.A. Abdusalam, Hassan Y. Aboul-Enein, and Hebatallah Wagdy

Novel Anti-arthritic Mechanisms of Polydatin in Complete Freund’s Adjuvant-Induced Arthritis in Rats: Involvement of IL-6, STAT-3, IL-17, and NF-кB, Kamel M. Kamel, Amany M. Gad, Suzan M. Mansour, Marwa M. Safar, and Hala M. Fawzy

Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway, Dina M. Lotfy, Marwa M. Safar, Seham H. Mohamed, and Sanaa A. Kenawy

REST overexpression in mice causes deficits in spontaneous locomotion, Li Lu, Anantha Marisetty, Bin Liu, Mohamed M. Kamal, Joy Gumin, Bethany Veo, You Qing Cai, Dina Hamada Kassem, Connie Weng, Mark E. Maynard, Kimberly N. Hood, Gregory N. Fuller, Zhizhong Z. Pan, Matthew D. Cykowski, Pramod K. Dash, and Sadhan Majumder

Efficient One-Pot, Two-Component Modular Synthesis of 3,5-Disubstituted Pyrazoles, Samy Mohamady, Braden Kralt, Shery K. Samwel, and Scott D. Taylor

Synthesis of Nucleoside-5′-O-Tetraphosphates from Activated Trimetaphosphate and Nucleoside-5′-O-Monophosphates, Samy Mohamady and Scott D. Taylor

A coumarin with an unusual structure from Cuphea ignea, its cytotoxicity and antioxidant activities, E. S. Moustafa, Noha Swilam, O. B. Ghanem, A. N. Hashim, M. A. Nawwar, U. Lindequist, and M. W. Linscheid

Different spectrophotometric methods for simultaneous determination of trelagliptin and its acid degradation product, Shereen Mowaka, Bassam M. Ayoub, Mostafa A. Hassan, and Wafaa A. Zaghary

A Replication Study for Association of LBX1 Locus With Adolescent Idiopathic Scoliosis in French-Canadian Population, Dina Nada, cedric Julien, Mark E. Samuels, and Alain Moreau

A replication study for association of LBX1 locus with adolescent idiopathic scoliosis in French-canadian population, Dina Nada, Cédric Julien, Mark E. Samuels, and Alain Moreau

Biochemistry of idiopathic scoliosis: From discovery to diagnostic biomarkers, Dina Nada and Alain Moreau

Biochemistry of Idiopathic Scoliosis: From Discovery to Diagnostic Biomarkers.Book; Pathogenesis of Idiopathic Scoliosis,, Dina Nada and Alain Moreau

Spray dried lactose based proniosomes as stable provesicular drug delivery carriers: Screening, formulation, and physicochemical characterization, Ali Nasr, Mona Qushawy, and Shady Swidan

Polyphenols LC-MS2 profile of Ajwa date fruit (Phoenix dactylifera L.) and their microemulsion: Potential impact on hepatic fibrosis, Khaled Nematallah, Nahla A. Ayoub, Essam Abdelsattar, Meselhy R. Meselhy, Mohamed M. Elmazar, Ahmed H. El-Khatib, Michael W. Linscheid, Rania M. Hathout, Kavitha Godugu, Aya Adel, and Shaker A. Mousa

Serum Vitamin D and Its Upregulated Protein, Thioredoxin Interacting Protein, Are Associated With Beta-Cell Dysfunction in Adult Patients With Type 1 and Type 2 Diabetes, Doaa F. Omar, Mohamed M. Kamal, Mohamed H. El-Hefnawy, and Hala Osman EL-Mesallamy

Mass spectrometric epitope mapping, Kwabena F.M. Opuni, Mahmoud Al-Majdoub, Yelena Yefremova, Reham F. El-Kased, Cornelia Koy, and Michael O. Glocker

Design, optimization and characterization of a transfersomal gel using miconazole nitrate for the treatment of candida skin infections, Mona Qushawy, Ali Nasr, Mohammed Abd-Alhaseeb, and Shady Swidan

The sole and combined effect of simvastatin and platelet rich fibrin as a filling material in induced bone defect in tibia of albino rats, Shereen N. Raafat, Reham M. Amin, Mohamed M. Elmazar, Mahmoud M. Khattab, and Aiman S. El-Khatib

A novel protocol for bacterial ghosts’ preparation using tween 80, Sameh Rabea, Mounir M. Salem-Bekhit, Fars K. Alanazi, Aymen S. Yassin, Nayera A. Moneib, and Abdel Gawad M. Hashem

Neurotherapeutic Effects of Bee Venom in a Rotenone-Induced Mouse Model of Parkinson’s Disease, M. K. Rakha, Rasha A. Tawfiq, R. A. Tawfiq, Mina Malak, M. A. Anwer, S. M. Salama, A. F. Mohamed, M. G. El-Hendy, Sh E. El-Said, N. M. Ahmed, K. S. Mekawi, A. M.Abd El-Aziz, and Mohamed M. Elmazar

UPLC/QTOF/MS profiling of two Psidium species and the in-vivo hepatoprotective activity of their nano-formulated liposomes, Fatema R. Saber, Ghada A. Abdelbary, Maha M. Salama, Dalia O. Saleh, Magda M. Fathy, and Fathy M. Soliman

The impact of seasonal variation on the volatile oil profile of leaves of Severinia buxifolia (Poir.) and its antimicrobial activity, Maha Salama, Mostafa Abdelkawy, Mohamed Saeed hifnawy, and Safaa Ahmed Nour

Polyphenols from Tamarix nilotica: LC–ESI-MSn profiling and in vivo antifibrotic activity, Ahmed Sekkien, Noha Swilam, Sherif S. Ebada, Ahmed Esmat, Ahmed H. El-Khatib, Michael W. Linscheid, and Abdel Nasser Singab

A Novel Role of Irbesartan in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats: Targeting DDAH/ADMA and EGFR/ERK Signaling, Nancy N. Shahin, Noha F. Abdelkader, and Marwa M. Safar

DOE, formulation, and optimization of Repaglinide nanostructured lipid carriers, Shady Swidan, Zeinab N. Mansour, Zeinab A. Mourad, Nahla A. Elhesaisy, Nada A. Mohamed, Mohamed S. Bekheet, Mohamed A. Badawy, Mai M. Elsemeiri, Aya E. Elrefaey, and Amera M. Hassaneen

Non-ionic surfactant based vesicular drug delivery system for topical delivery of caffeine for treatment of cellulite: design, formulation, characterization, histological anti-cellulite activity, and pharmacokinetic evaluation, Mahmoud H. Teaima, Sally A. Abdelhalim, Mohamed A. El-Nabarawi, Dalia Attia, and Doaa A. Helal

A Novel Role of a Chemotherapeutic Agent in a Rat Model of Endotoxemia: Modulation of the STAT-3 Signaling Pathway, Omnia S. Zaki, Marwa M. Safar, Afaf A. Ain-Shoka, and Laila A. Rashed

Bone Marrow Mesenchymal Stem Cells Combat Lipopolysaccharide-Induced Sepsis in Rats via Amendment of P38-MAPK Signaling Cascade, Omnia S. Zaki, Marwa M. Safar, Afaf A. Ain-Shoka, and Laila A. Rashed

Submissions from 2017

Neuroprotective Effect of Nanodiamond in Alzheimer’s Disease Rat Model: a Pivotal Role for Modulating NF-κB and STAT3 Signaling, Shawqi H. Alawdi, Ezzeldin S. El-Denshary, Marwa M. Safar, Housam Eidi, Marie Odile David, and Mosaad A. Abdel-Wahhab

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DOE Optimization of Nano-based Carrier of Pregabalin as Hydrogel: New Therapeutic &chemometric Approaches for Controlled Drug Delivery Systems, Mona Arafa and Bassam M. Ayoub

Nano-vesicles of salbutamol sulphate in metered dose inhalers: Formulation, characterization and in vitro evaluation, Mona Arafa and Bassam M. Ayoub

Economic evaluation of imipenem-cilastatin versus doripenem in ventilator-associated pneumonia in Egypt, Nermeen Ashoush

Review on pharmacokinetics of empagliflozin, an inhibitor of the sodium-glucose cotransporter-2, Nermeen Ashoush

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Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study, Dalia Attia, Shaimaa El-Housiny, Maii Atef Shams Eldeen, Yasmina Ahmed El-Attar, Hoda Salem, Ehab Bendas, and Mohamed El-Nabarawi

The FXR Agonist, Obeticholic Acid, Suppresses HCC Proliferation & Metastasis: Role of IL-6/STAT3 Signalling Pathway, Yasmeen M. Attia, Rasha A. Tawfiq, Aya A. Ali, and Mohamed M. Elmazar

Green pharmaceutical analysis of drugs coformulated with highly different concentrations using spiking and manipulation of their ratio spectra, Bassam M. Ayoub

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Quantitative Analysis of Drugs with Highly Different Concentrations of Pharmaceutical Components Using Spectral Subtraction Techniques, Bassam M. Ayoub

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Mean centering method for determination of empagliflozin and metformin, Bassam M. Ayoub, Rola M. Emam, Mahmoud M. Youssef, Muhammad N. El-Kattan, Marwa A. Sayed, Ahmed M. Kowider, Adly H. Seha, Engy A. Rabea, Rana M. Yakout, and Rolly H. Faried

LC-MS/MS determination of empagliflozin and metformin, Bassam M. Ayoub and Shereen Mowaka

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Pharmacokinetic Evaluation of Empagliflozin in Healthy Egyptian Volunteers Using LC-MS/MS and Comparison with Other Ethnic Populations, Bassam M. Ayoub, Shereen Mowaka, Eman S. Elzanfaly, Nermeen Ashoush, Mohamed M. Elmazar, and Shaker A. Mousa

A validated HPLC method for simultaneous determination of perindopril arginine, amlodipine, and indapamide: Application in bulk and in different pharmaceutical dosage forms, Ramzia I. El-Bagary, Ehab F. Elkady, Shereen Mowaka, and Maria A. Attallah

Honey-based hydrogel: In vitro and comparative in vivo evaluation for burn wound healing, Reham F. El-Kased, Reham I. Amer, Dalia Attia, and Mohamed M. Elmazar

IDH Mutation, Competitive Inhibition of FTO, and RNA Methylation, Sara M. Elkashef, An Ping Lin, Jamie Myers, Heinz Sill, Daifeng Jiang, Patricia L.M. Dahia, and Ricardo C.T. Aguiar

Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis, Naglaa M. El-Lakkany, Walaa H. El-Maadawy, Sayed H. Seif el-Din, Olfat A. Hammam, Salwa H. Mohamed, Shahira M. Ezzat, Marwa M. Safar, and Samira Saleh

EVESOR, a model-based, multiparameter, Phase i trial to optimize the benefit/toxicity ratio of everolimus and sorafenib, Mévidette El-Madani, Olivier Colomban, Michel Tod, Denis Maillet, Julien Peron, Claire Rodriguez-Lafrasse, Osama A. Badary, Pierre Jean Valette, Thibaud Lefort, Philippe Cassier, Siham M. El-Shenawy, Ebtehal El-Demerdash, Juliette Hommel-Fontaine, Jerome Guitton, Marie Claude Gagnieu, Bassant M.M. Ibrahim, Catherine Barrois, Gilles Freyer, and Benoit You

Synthesis of new thieno[2,3-b]pyridine derivatives as pim-1 inhibitors, Hala B. El-Nassan and Bassem H. Naguib

Antiprotozoal activity of major constituents from the bioactive fraction of Verbesina encelioides, Shahira M. Ezzat, Maha M. Salama, Engy A. Mahrous, Louis Maes, Cheol Ho Pan, and Essam Abdel-Sattar

Volatiles profiling in Ceratonia siliqua (Carob bean) from Egypt and in response to roasting as analyzed via solid-phase microextraction coupled to chemometrics, Mohamed A. Farag and Dina M. El-Kersh

Volatiles distribution in Nigella species (black cumin seeds) and in response to roasting as analyzed via solid-phase microextraction (SPME) coupled to chemometrics, Mohamed A. Farag, Dina M. El-Kersh, Dalia M. Rasheed, and Andreas G. Heiss

Advances in ligase chain reaction and ligation-based amplifications for genotyping assays: Detection and applications, Abdullah A.Y. Gibriel and Ola Adel

Biofilm formation in enterococci: Genotype-phenotype correlations and inhibition by vancomycin, Yomna Hashem, Heba M. Amin, Tamer M. Essam, Aymen S. Yassin, and Ramy K. Aziz

Telluric Acid Ameliorates Endotoxemic Kidney Injury in Mice: Involvement of TLR4, Nrf2, and PI3K/Akt Signaling Pathways, Ahmed F. Mohamed, Marwa M. Safar, Hala F. Zaki, and Helmy M. Sayed

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra, Ekram Hany Mohamed, Hayam M. Lotfy, Maha A. Hegazy, and Shereen Mowaka

Comparative study between UHPLC-UV and UPLC-MS/MS methods for determination of alogliptin and metformin in their pharmaceutical combination, Shereen Mowaka and Bassam M. Ayoub

Enhanced LC-MS/MS determination of alogliptin and metformin in plasma: Application to a pharmacokinetic study, Shereen Mowaka, Ehab F. Elkady, Mohamed M. Elmazar, and Bassam M. Ayoub

Novel pure component contribution algorithm (PCCA) and UHPLC methods for separation and quantification of amlodipine, valsartan, and hydrochlorothiazide in ternary mixture, Shereen Mowaka, Maha A. Hegazy, Hayam M. Lotfy, and Ekram Hany Mohamed

A Concise Comparative Mini Review between HPLC-UV and Spectrophotometric Analysis of Gliptins in Pharmaceutical Formulations, Shereen Mowaka, Moataz S. Hendy, Mohamed M. Elmazar, Andrew Hakeem, Ramzia I. El-Bagary, Ehab F. Elkady, Mirna Antoun, Mai Shaalan, Sara Abdel-wahab, Mai Elsemeiri, Nourhan Abdelaziz, Alaa Mohamed, Menna Eltahawy, Asmaa Rashid, Rola Emam, Mahmoud Youssef, Muhammad El-kattan, Marwa Sayed, and Bassam M. Ayoub

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Synthesis of New Pyridothienopyrimidinone and Pyridothieno -triazolopyrimidine Derivatives as Pim-1 Inhibitors, Bassem Naguib, Hala B. El-Nassan, and Engy A. Beshay

Synthesis of new pyridothienopyrimidinone derivatives as Pim-1 inhibitors, Bassem H. Naguib, Hala B. El-Nassan, and T. M. Abdelghany

Randomized double-blinded pilot clinical study of the antidiabetic activity of balanites aegyptiaca and uplc-esi-ms/ms identification of its metabolites, Hend Rashad, Fateheya M. Metwally, Shahira M. Ezzat, Maha M. Salama, Adel Hasheesh, and Amira Abdel Motaal

Association of serum pancreatic derived factor (PANDER) with beta-cell dysfunction in type 2 diabetes mellitus, Miral M. Shehata, Mohamed M. Kamal, Mohamed H. El-Hefnawy, and Hala O. EL-Mesallamy

Ischemia-responsive protein 94 is a key mediator of ischemic neuronal injury-induced microglial activation, Rajiv Tikamdas, Sarthak Singhal, Ping Zhang, Justin A. Smith, Eric G. Krause, Stanley M. Stevens, Sihong Song, and Bin Liu

Mass spectrometric characterization of protein structures and protein complexes in condensed and gas phase, Yelena Yefremova, Bright D. Danquah, Kwabena F.M. Opuni, Reham F. El-Kased, Cornelia Koy, and Michael O. Glocker

Anti-tumor efficacy of an integrated methyl dihydrojasmonate transdermal microemulsion system targeting breast cancer cells: In vitro and in vivo studies, Rania Yehia, Rania M. Hathout, Dalia A. Attia, Mohamed M. Elmazar, and Nahed D. Mortada

Comparative study between different simple methods manipulating ratio spectra for the analysis of alogliptin and metformin co-formulated with highly different concentrations, Wafaa A. Zaghary, Shereen Mowaka, Mostafa A. Hassan, and Bassam M. Ayoub

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Suitability of various chromatographic and spectroscopic techniques for analysis and kinetic degradation study of trelagliptin, Wafaa A. Zaghary, Shereen Mowaka, Mostafa A. Hassan, and Bassam M. Ayoub

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Comparative liquid chromatographic study for concurrent determination of canagliflozin and metformin in combined tablets, Wafaa A. Zaghary, Shereen Mowaka, and Moataz S. Hendy

Submissions from 2016

Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson’s Disease: Modulation of Mitochondrial Perturbations, Noha F. Abdelkader, Marwa M. Safar, and Hesham A. Salem

Indole-3-carbinol enhances sorafenib cytotoxicity in hepatocellular carcinoma cells: A mechanistic study, Mai M. Abdelmageed, Reem N. El-Naga, Ebtehal El-Demerdash, and Mohamed M. Elmazar

Glucosinolates profile, volatile constituents, antimicrobial, and cytotoxic activities of Lobularia libyca, Amal A. Al-Gendy, Khaled A. Nematallah, Soumaya S. Zaghloul, and Nahla A. Ayoub

Mini-review and comparative study: preparation and evaluation of nicotine-loaded buccal mucoadhesive tablets/films designed for smoking cessation, Mona Arafa and Bassam M. Ayoub

Polyphenols from Erythrina crista-galli: Structures, molecular docking and phytoestrogenic activity, Naglaa S. Ashmawy, Mohamed L. Ashour, Michael Wink, Mohamed El-Shazly, Fang Rong Chang, Noha Swilam, Ashraf B. Abdel-Naim, and Nahla Ayoub

Mini-review: Pharmacokinetics of omarigliptin, a once-weekly dipeptidyl peptidase-4 inhibitor, Nermeen Ashoush

Application of spiking technique coupled with derivative spectrophotometry for the analysis of a novel anti-diabetic combination of two coformulated drugs with highly different concentrations, Bassam M. Ayoub

Development and validation of simple spectrophotometric and chemometric methods for simultaneous determination of empagliflozin and metformin: Applied to recently approved pharmaceutical formulation, Bassam M. Ayoub

Enhancement of plasma extraction recovery of empagliflozin and metformin combination using liquid-liquid extraction and vacuum evaporation techniques, Bassam M. Ayoub

Linagliptin: A concise review on analytical and bio-analytical methods, Bassam M. Ayoub

Mini-review: Analytical procedures for alogliptin determination in biological fluids and pharmaceutical formulations, Bassam M. Ayoub

A guide for using experimental design in chromatographic method development: Applied to the analysis of selected anti-diabetic pharmaceutical combinations, Bassam M. Ayoub and O. Abdel-Aziz

Review of HPLC/UPLC-UV methods for sensitive determination of nicotine in plasma, Bassam M. Ayoub, Mona Arafa, and Moataz S. Hendy

Economic Evaluation of the Combined Use of Warfarin and Low-dose Aspirin Versus Warfarin Alone in Mechanical Valve Prostheses, Manal H. El-Hamamsy, Gihan H. Elsisi, Randa Eldessouki, Mohamed M. Elmazar, Ahmed S. Taha, Basma F. Awad, and Hossam Elmansy

Natural antibacterial remedy for respiratory tract infections, Reham F. El-Kased

Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment, Sara M. Elkashef, Simon J. Allison, Maria Sadiq, Haneen A. Basheer, Goreti Ribeiro Morais, Paul M. Loadman, Klaus Pors, and Robert A. Falconer

An optimised assay for quantitative, high-throughput analysis of polysialyltransferase activity, Sara M. Elkashef, Mark Sutherland, Laurence H. Patterson, Paul M. Loadman, and Robert A. Falconer

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Cytotoxicity and Chemical Investigation of the Aerial Parts of Markhamia zanzibarica (Bojer Ex Dc.) K. Schum. (Bignoniaceae), Dina M. El-Kersh, Riham S. El Dine, Dina R. Abou-Hussein, Fatma S. El-Sakhawy, and Mohamed M. Elmazar

Use of random amplified polymorphic DNA (RAPD) technique to study the genetic diversity of eight aloe species, Shahira M. Ezzat, Abeer M. El Sayed, and Maha M. Salama

HPLC–DAD–MS/MS profiling of standardized rosemary extract and enhancement of its anti-wrinkle activity by encapsulation in elastic nanovesicles, Shahira M. Ezzat, Maha M. Salama, Aliaa N. ElMeshad, Mahmoud H. Teaima, and Laila A. Rashad

Metabolic profile and hepatoprotective activity of the anthocyanin-rich extract of Hibiscus sabdariffa calyces, Shahira M. Ezzat, Maha M. Salama, Sayed H. Seif el-Din, Samira Saleh, Naglaa M. El-Lakkany, Olfat A. Hammam, Maha B. Salem, and Sanaa S. Botros

Anti-acetylcholinesterase potential and metabolome classification of 4 Ocimum species as determined via UPLC/qTOF/MS and chemometric tools, M. A. Farag, S. M. Ezzat, Maha M. Salama, and M. G. Tadros

Anti-acetylcholinesterase activity of essential oils and their major constituents from four Ocimum species, Mohamed A. Farag, Shahira M. Ezzat, Maha M. Salama, Mariane G. Tadros, and Rabah A.T. Serya

Square wave voltammetric determination of rasagiline mesylate on hanging mercury drop electrode and its application in dosage form and biological fluids, Ibrahim H.I. Habib, Mohamed Rizk, Dalia Mohamed, Shereen Mowaka, and Rasha Th El-Eryan