Submissions from 2021
Nanographene Oxide for Enhanced Dissolution Rate and Antibacterial Activity of Cefdinir, Dina E. Bali, Mona F. Arafa, Noha M. Gamaleldin, and Gamal M. El Maghraby
SRD5A3-CDG: 3D structure modeling, clinical spectrum, and computer-based dysmorphic facial recognition, I Ben-Ayed, W Ouarda, F Frikha, F Kammoun, A Souissi, M Ben Said, A Bouzid, I Elloumi, T Hamdani, N Gharbi, N Baklouti, M Guirat, F Mejdoub, N Kharrat, I Boujelbene, F Abdelhedi, N Belguith, L Keskes, A GIBRIEL, H Kamoun, C Triki, A Alimi, and S MASMOUDI
Potential of Magnetic Hyperthermia to Stimulate Localized Immune Activation, Thomas J. Carter, Giulia Agliardi, Fang-Yu Lin, Matthew Ellis, Clare Jones, Mathew Robson, Angela Richard-Londt, Paul Southern, Mark Lythgoe, May Zaw Thin, Vyacheslav Ryzhov, Rafael T. M. de Rosales, Cordula Gruettner, Maha R.A. Abdollah, R. Barbara Pedley, Quentin A. Pankhurst, Tammy L. Kalber, Sebastian Brandner, Sergio Quezada, Paul Mulholland, Maxim Shevtsov, and Kerry Chester
Characterization of Four Piper Essential Oils (GC/MS and ATR-IR) Coupled to Chemometrics and Their anti- Helicobacter pylori Activity, Dina M. El-Kersh, Eman Al-Sayed, and Haidy Gad
A Literature-Based Update on Benincasa hispida (Thunb.) Cogn.: Traditional Uses, Nutraceutical, and Phytopharmacological Profiles, Dina M. El-Kersh; Muhammad Torequl Islam,; Cristina Quispe,; Manik Chandra Shill,; Kanchan Bhardwaj,; Prerna Bhardwaj,; Javad Sharifi-Rad,; Miquel Martorell,; Rajib Hossain,; Ahmed Al-Harrasi,; Ahmed Al-Rawahi,; and Monica Butnariu,
Monocyte monolayer assay in pre-transfusion testing: A magic key in transfusing patients with recurrent bad cross-match due to alloimmunization, Hebat Allah N. El-sayed, Maha R.A. Abdollah, Shereen N. Raafat, and Dina Ragab
Novel pathogenic mutations and further evidence for clinical relevance of genes and variants causing hearing impairment in Tunisian population, Abdullah A.Y. Gibriel, A Souissi, M BEN SAID, I Ben Ayed, I Elloumi, A Bouzid, M Mosrati, M Hasnaoui, M Belcadhi, N Idriss, H Kamoun, N Gharbi, Abdullah Gibriel, A Tlili, and S MASMOUDI
Glucose and fatty acid metabolism involved in the protective effect of metformin against ulipristal-induced endometrial changes in rats, Marwa S. Hamza, Eman Ramadan, and Salama A. Salama
New emerging roles of the novel hepatokine SERPINB1 in type 2 diabetes mellitus: Crosstalk with b-cell dysfunction and dyslipidemia, Mohamed M. Kamal, Aya A. Ali, Ghada H. Sayed, Shadia Ragab, and Dina H. Kassem
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage, Amira Khalil, Mirat Sojitra, Jasmine Maghera, Emily Rodrigues, Eric J. Carpenter, Shaurya Seth, Daniel Ferrer Vinals, and Todd L. Lowary
Validation of a novel UPLC-MS/MS method for estimation of metformin and empagliflozin simultaneously in human plasma using freezing lipid precipitation approach and its application to pharmacokinetic study, Ekram Hany Mohamed; Mona N. Abou-Omar,; Mohamed S. S. Attia; Ahmed O. Youssef; Sarah Alharthi,; and M. Kenawy
Novel Optical Biosensor Based on a Nano-Gold Coated by Schiff Base Doped in Sol/Gel Matrix for Sensitive Screening of Oncomarker CA-125, Ekram Hany Mohamed; Mohamed S. S. Attia; Mona N. Abou-Omar,; Mohammed A. Amin,; Rabah Boukherroub; and hisham afify
Simultaneous determination of Avanafil and Dapoxetine in human plasma using liquid chromatography/tandem mass spectrometry (LC-MS/MS) based on a protein precipitation technique, Ekram Hany Mohamed; Mohamed S. S. Attia; Mona N. Abou-Omar,; Abdelaziz M Annadi,; Ahmed O. Youssef; Mohamed A. AMIN; and Noha M. El Zahar,
Tb3+-atorvastatin doped in poly(ethylene glycol) optical biosensor for selective determination of progesterone and testosterone in serum samples, Ekram Hany Mohamed; Mohamed S. S. Attia; Safwat A. Mahmoud,; Amal M. Ahmed,; Tarek A. Amin; Ahmed O. Youssef; Mona N. Abou-Omar,; and Mohammed A. c Amin,
New Tb3+-simvastatin optical biosensor for sensitive determination of folic acid, progesterone, testosterone and vitamin D3in biological fluids, Ekram Hany Mohamed; Mohamed S. S. Attia; Ahmed O. Youssef; Mona N. Abou-Omar,; Amal M. Ahmed,; Safwat A. Mahmoud,; Mohammed A. Amin; and tarek A. Mahmoud,
All solid-state miniaturized potentiometric sensors for flunitrazepam determination in beverages, Ekram Hany Mohamed, Mahmoud tantawy, and ali yahia
Deep analysis of the LRTOMTc.242G>A variant in non-syndromic hearing loss North African patients and the Berber population: Implications for genetic diagnosis and genealogical studies, M MOSRATI, K Fadhlaoui-Zid, A Benammar- Elgaaied, Abdullah Gibriel, M Ben Said, and S MASMOUDI
Investigation of Pharmacokinetic Parameters of Trelagliptin in Egyptian Volunteers Using Sensitive LC-MS/MS: A Comparative Study with a Japanese Population, Shereen Mowaka, Nermeen Ashoush, Mariam M. Tadros, and Bassam Ayoub
Electrochemical Determination of Ipragliflozin in Pure Form and in Spiked Human Plasma on a Glassy Carbon Electrode, Shereen Mowaka, Manar M. Elhassan, Amr M. Mahmoud, and Maha A. Hegazy
In-line monitoring of sitagliptin dissolution profile from tablets utilizing an eco-friendly potentiometric sensor, Shereen Mowaka, Manar M. Elhassan, Amr M. Mahmoud, and Maha A. Hegazy
Fabrication and characterization of Agarwood extract-loaded nanocapsules and evaluation of their toxicity and anti-inflammatory activity on RAW 264.7 cells and in zebrafish embryos, Eman Ramadan, Manar A. Eissa, and Noha Badawi
Comparing the protective effects of resveratrol, curcumin and sulforaphane against LPS/IFN-γ-mediated inflammation in doxorubicin-treated macrophages, Eman Ramadan, Mohey Elmazar, and Haidy A. Saleh
'Induction of apoptosis, cytotoxicity and radiosensitization by novel 3,4-dihydroquinazolinone derivatives, Eman Ramadan and amira khalil
Novel mechanistic insights towards the repositioning of alogliptin in Parkinson's disease, Eman Ramadan and marwa M. Safar
Novel mechanistic insights towards the repositioning of alogliptin in Parkinson's disease., Marwa Safar
Rutin Ameliorates Hepatic Fibrosis via Targeting Hepatic Stellate Cells’ Activation, Proliferation and Apoptosis, Marwa Safar
Anti‑estrogenic and anti‑aromatase activities of citrus peels major compounds in breast cancer, Maha Salama, Dina Mahmoud ElKersh, Shahira M. Ezzat, Yasmeen Attiaa, Engy A. Mahrous, and Mohey ElMazar
Downregulation of MMP1 expression mediates the anti-aging activity of Citrus sinensis peel extract nanoformulation in UV induced photoaging in mice, Maha Salama, October University for Modern Sciences & Arts, and The British University in Egypt
Obesity and depression: Could some shared genes explain the relationship?, Moustafa Sayed and Nouran Yonis
Genetics and meta-analysis of recessive non-syndromic hearing impairment and Usher syndrome in Maghreb population: lessons from the past, contemporary actualities and future challenges, A Souissi, Abdullah Gibriel, and S MASMOUDI
Green Synthesized Honokiol Transfersomes Relieve the Immunosuppressive and Stem-Like Cell Characteristics of the Aggressive B16F10 Melanoma, Shady Swidan, Yasmeen Ezzeldeen, Aya Sebak, and Aliaa N. ElMeshad
Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole-and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein, Shady Swidan, Ali Nasr, Mona K. Qushawy, Manar Nagy, Khalid Darwish, Samia Mostafa, Ismail Salama, and Mohaamed Tantawy
GC/MSProfilingandExVivoAntibacterialActivityofSalvadora persica (Siwak) against Enterococcus faecalis as Intracanal Medicament, Noha Swilam; Nahla Ayoub; Nadia Badr; Saeed S Al-Ghamdi,; Arwa Alzahrani; Rahaf Alsulaimani; Afnan Nassar; and Rawabi Qadi
A Unique Acylated Flavonol Glycoside from Prunus persica (L.) var. Florida Prince: a New Solid Lipid Nanoparticle Cosmeceutical Formulation for Skincare, Noha Swilam, Eman Mostafa, Ahmed Maher, Dalia Mostafa, Sameh Gad, and Mahmoud Nawwar
Circulatory miR-221 & miR-542 expression profiles as potential molecular biomarkers in Hepatitis C Virus mediated liver cirrhosis and hepatocellular carcinoma, M YASSER, M AbdellatiF, E EMAD, A JAFER, S AHMED, L NAGEB, H Abdelshafy, A Al-anany, M Al-Arab, and A Gibriel
Submissions from 2020
Metallopharmaceutical complexes based on vanadium as potential anti-hyperglycemic agents, R. M. Abd-Elaziz, A. S. El-Tabl, Mohamed M. Elmazar, and M. M. Abd-Elwahed
Effects of TNF-α antagonist infliximab on fructose-induced metabolic syndrome in rats, Yasmine A. Abdelhamid, Mohammed F. Elyamany, Muhammad Y. Al-Shorbagy, and Osama A. Badary
Olmesartan attenuates type 2 diabetes-associated liver injury: Cross-talk of AGE/RAGE/JNK, STAT3/SCOS3 and RAS signaling pathways, Nesma M.E. Abo El- Nasr, Dalia Osama Saleh, Sawsan S. Mahmoud, Salwa M. Nofal, Rania M. Abdelsalam, Marwa M. Safar, and Hanan S. El-Abhar
Development and validation of HPLC-UV method for the determination of a potent synthetic cannabinoid THJ-2201 in mouse plasma and application in a pharmacokinetic study, Hassan Y. Aboul-Enein, Gamal A.E. Mostafa, Haitham Alrabiah, Mohammed Al-Ramadi, Sabry M. Attia, and Hebatallah Wagdy
Investigating circulatory microRNA expression profiles in Egyptian patients infected with hepatitis C virus mediated hepatic disorders, Amany Al-Anany, Mohamed Al-Arab, Hassan Azzazy, and Abdullah Gibriel
Synthesis and Docking Studies of a Novel Tetrahydroquinazoline Derivative as Promising Scaffold for Acetylcholine Esterase Inhibition, Amgad Albohy; Rawan A. , Alsuhaimat; Qais Abualassal; Zead Helmi Abudayeh; and Sherif S. Ebada
Publisher Correction: Propolis-based niosomes as oromuco-adhesive films: A randomized clinical trial of a therapeutic drug delivery platform for the treatment of oral recurrent aphthous ulcers (Scientific Reports, (2018), 8, 1, (18056), 10.1038/s41598-018-37157-7), Mona G. Arafa, Dalia Ghalwash, Dina M. El-Kersh, and Mohamed M. Elmazar
Chitosan-coated PLGA nanoparticles for enhanced ocular anti-inflammatory efficacy of atorvastatin calcium, Mona Arafa, Germeen N.S. Girgis, and Marwa S. El-Dahan
Preparation of PLGA-chitosan based nanocarriers for enhancing antibacterial effect of ciprofloxacin in root canal infection, Mona Arafa, Hadeel A. Mousa, and Nagia N. Afifi
Development of Pomegranate Extract-Loaded Solid Lipid Nanoparticles: Quality by Design Approach to Screen the Variables Affecting the Quality Attributes and Characterization, Dalia Attia, Noha Badawi, Khalid El-Say, Mohamed El-Nabarawi, mohamed Elmazar, and Mahmoud Teaima
Management of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges: in-vitro and in-vivo evaluation, Dalia Attia, Muhammed Ossama, Caroline Lamie, Mohamed Tarek, Hebatallah Wagdy, and mohamed Elmazar
Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer, Yasmeen M. Attia, Dina M. El-Kersh, Reham A. Ammar, Aliaa Adel, Aya Khalil, Hoda Walid, Kirullos Eskander, Mohamed Hamdy, Nada Reda, Nour Elhoda Mohsen, Ghada M. Al-Toukhy, Mohamed Tarek Mansour, and Mohamed M. Elmazar
Successful Stories of Drug Repurposing for Cancer Therapy in Hepatocellular Carcinoma, To and Cho_Drug Repurposing in Cancer Therapy, Yasmeen M. Attia, Heba Ewida, and Mahmoud Ahmed
Crosstalk between aldehyde dehydrogenase-1 and chemoresistance in breast cancer: Insights into the role of vitamin D3, Yasmeen M. Attia, Olfat A. Hammam, Reham A. Ammar, Mohamed T. Mansour, and Mohamed M. Elmazar
COVID-19 vaccination clinical trials should consider multiple doses of BCG, Bassam M. Ayoub
Multifaceted repurposing of flozins, glitazones, gliptins and GLP-1 agonists as potential pluritherapeutic agents, Bassam M. Ayoub
Rosuvastatin dose should be case individualized: An observation from inherited hypercholesterolemia case study, Bassam M. Ayoub, Nermeen Ashoush, Mariam M. Tadros, Noha M. Elzahar, Moataz S. Hendy, and Shereen Mowaka
Avoiding COVID-19 complications with diabetic patients could be achieved by multi-dose Bacillus Calmette–Guérin vaccine: a case study of beta cells regeneration, Bassam M. Ayoub, Eman Ramadan, Nermeen Ashoush, Mariam M. Tadros, Moataz S. Hendy, Mohamed M. Elmazar, and Shaker A. Mousa
Preprint (medicine & pharmacology, preprints.org): Avoiding COVID-19 Complications with Diabetic Patients Could Be Achieved by Multi-Dose BCG Vaccine: A Case Study of Beta Cells Regeneration by Serendipity, Bassam Ayoub, Eman Ramadan, Nermeen Ashoush, Mariam M. Tadros, Moataz S. Hendy, Mohamed M. Elmazar, and Shaker Mousa
In vivo antiulcer activity, phytochemical exploration, and molecular modelling of the polyphenolic-rich fraction of Crepis sancta extract, Sherif S. Ebada, Nariman A. Al-Jawabri, Fadia S. Youssef, Amgad Albohy, Sa’ed M. Aldalaien, Ahmad M. Disi, and Peter Proksch
Metabolite profiling of aquilaria malaccensis leaf extract using liquid chromatography-Q-TOF-mass spectrometry and investigation of its potential antilipoxygenase activity in-Vitro, Manar A. Eissa, Yumi Z.H.Y. Hashim, Dina M. El-Kersh, Saripah S.S. Abd-Azziz, Hamzah Mohd Salleh, Muhammad Lokman Md Isa, and Nor Malia Abd Warif
Trazodone Loaded Lipid Core Poly (ε-caprolactone) Nanocapsules: Development, Characterization and in Vivo Antidepressant Effect Evaluation, Nahla Elhesaisy and Shady Swidan
Vitamin D3 Ameliorates DNA Damage Caused by Developmental Exposure to Endocrine Disruptors in the Uterine Myometrial Stem Cells of Eker Rats, Hoda Elkafas, Mohamed Ali, Engy Elmorsy, Rehab Kamel, Winston E. Thompson, Osama A. Badary, Ayman Al-Hendy, and Qiwei Yang
Development of a specific troponin i detection system with enhanced immune sensitivity using a single monoclonal antibody: Troponin (cTnI) Detection, Reham F. El-Kased, Anil Bozdogan, Vanessa Jungbluth, Wolfgang Knoll, Jakub Dostalek, and Amal Kasry
Prevalence of Bacteria in Primary schools, Reham F. El-Kased and Noha M. Gamaleldin
Aquilaria species as potential anti-inflammatory agents–a review on in vitro and in vivo studies, Dina M. El-Kersh; Manar Eissa,; Yumi Z. Hashim,; Hamzah Mohd. Salleh,; Saripah S. S. Abd-Azziz,; Muhammad Lokman Md. Isa,; Nor Malia Abd Warif,; Yusilawati Ahmad Nor,; and Muhamad Shirwan Abdullah Sani
Herbal cosmeticology, Dina M. El-Kersh; Mahitab El Bishbishy,; Shahira Ezzat; Mohamed Salem,; and Maha Salama,
Dietary Xanthones, Dina M. El-Kersh, Mohamed A. Farag, Hesham R. ElSeedi, and Omar M. Khattab
The novel SOD mimetic GC4419 increases cancer cell killing with sensitization to ionizing radiation while protecting normal cells, Mohamed A. El-Mahdy, Yasmin A. Alzarie, Craig Hemann, Osama A. Badary, Shahira Nofal, and Jay L. Zweier
Successive stability indicating spectrophotometric technique for simultaneous determination of quetiapine fumarate and its three major related compounds, Christine M. El-Maraghy and Ekram Hany Mohamed
Circulatory miRNA-484, 524, 615 and 628 expression profiling in HCV mediated HCC among Egyptian patients; implications for diagnosis and staging of hepatic cirrhosis and fibrosis, Shohda A. El-Maraghy, Ola Adel, Naglaa Zayed, Ayman Yosry, Saeed M. El-Nahaas, and Abdullah A.Y. Gibriel
Circulatory miRNA-484, 524, 615 and 628 expression profiling in HCV mediated HCC among Egyptian patients; implications for diagnosis and staging of hepatic cirrhosis and fibrosis, Shohda El-maraghy, Ola Adel, Naglaa Zayed, Ayman Yosry, Saeed El-Nahaas, and Abdullah Gibriel
Development of Advanced Chemometric-Assisted Spectrophotometric Methods for the Determination of Cromolyn Sodium and Its Alkaline Degradation Products, Noha M. Elzahar, Mariam M. Tadros, and Bassam Ayoub
Upregulation of MC4R and PPAR-α expression mediates the anti-obesity activity of Moringa oleifera Lam. in high-fat diet-induced obesity in rats, Shahira M. Ezzat, Mahitab H. El Bishbishy, Nora M. Aborehab, Maha M. Salama, Adel Hasheesh, Amira Abdel Motaal, Hend Rashad, and Fateheya M. Metwally
Tackling the various classes of nano-therapeutics employed in topical therapy of psoriasis, Salma A. Fereig, Ghada M. El-Zaafarany, Mona Arafa, and Mona M.A. Abdel-Mottaleb
Exploration of Chemical Diversity and Antitrypanosomal Activity of Some Red Sea-Derived Actinomycetes Using the OSMAC Approach Supported by LC-MS-Based Metabolomics and Molecular Modelling, Noha M. Gamaleldin, Waleed Bakeer, Ahmed M. Sayed, yara Shamikh, Hossam Hassan, Hannes Horn, Usama Abdelmohsen, Wael Hozzein, and Ahmed El-Gendy
Cross-Sectional Study on Awareness and Knowledge of COVID-19 Among Senior pharmacy Students, Marwa Hamza, Osama A. Badary, and Mohamed M. Elmazar
2-Methoxyestradiol inhibits high fat diet-induced obesity in rats through modulation of adipose tissue macrophage infiltration and immunophenotype, Marwa Hamza, Moustafa Sayed, and Salama Salama
Cancer-Associated Thrombosis: Risk Factors, Molecular Mechanisms, Future Management, Marwa S. Hamza and Shaker A. Mousa
Protective effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways, Mennat Allah M. Hassan, Amany M. Gad, Esther T. Menze, Osama A. Badary, and Reem N. El-Naga
Construction and assessment of a novel vaccine targeting hepatocellular carcinoma, Alyaa Farouk Hessin, Rehab Ragab Hegazy, Marwa M. Safar, Nemat Zakaria Yassin, and Sanaa Abdel Baky Kenawy
Effects of Chronic Caffeine Administration on Behavioral and Molecular Adaptations to Sensory Contact Model Induced Stress in Adolescent Male Mice, Michael Kamal Ibrahim, Mohamed Kamal, Rajiv Tikamdas, Roua Aref Nouh, Jiang Tian, and Moustafa Sayed
Effects of Chronic Caffeine Administration on Behavioral and Molecular Adaptations to Sensory Contact Model Induced Stress in Adolescent Male Mice, Micheal K. Ibrahim, Mohamed M. Kamal, Rajiv Tikamdas, Roua Aref Nouh, Jiang Tian, and Mostafa Sayed
Testosterone Undecanoate effects on behavior and Cognitive Functions in male swiss Albino mice exposed to Chronic Social Defeat, Micheal K. Ibrahim, Rajiv Tikamdas, Mohamed M. Kamal, Roua Aref Nouh, and Mostafa H. Sayed
Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data, Muhammad T. Islam, Chandan Sarkar, Dina M. El-Kersh, Sarmin Jamaddar, Shaikh J. Uddin, Jamil A. Shilpi, and Mohammad S. Mubarak
Therapeutic Potential of Wharton’s Jelly Mesenchymal Stem Cells for Diabetes: Achievements and Challenges, Mohamed M. Kamal and Dina H. Kassem
A Novel SERPINB1 Single-Nucleotide Polymorphism Associated With Glycemic Control and β-Cell Function in Egyptian Type 2 Diabetic Patients, Dina H. Kassem, Aya Adel, Ghada H. Sayed, and Mohamed M. Kamal
Mesenchymal Stem Cells and Their Extracellular Vesicles: A Potential Game Changer for the COVID-19 Crisis, Dina H. Kassem and Mohamed M. Kamal
Therapeutic efficacy of umbilical cordderived stem cells for diabetes mellitus: a meta-analysis study, Dina H. Kassem and Mohamed M. Kamal
Wharton's Jelly MSCs: Potential Weapon to Sharpen for Our Battle against DM, Dina H. Kassem and Mohamed M. Kamal
Telmisartan Protects Against Aluminum-Induced Alzheimer-like Pathological Changes in Rats, Mona Khalifa, Marwa M. Safar, Rania M. Abdelsalam, and Hala F. Zaki
Design and novel synthetic approach supported with molecular docking and biological evidence for naphthoquinone-hydrazinotriazolothiadiazine analogs as potential anticancer inhibiting topoisomerase-IIB, Samy Mohamady, Abdullah A.Y. Gibriel, Mahmoud Salama Ahmed, Moataz S. Hendy, and Bassem H. Naguib
Discovery of 5-aryl-3-thiophen-2-yl-1H-pyrazoles as a new class of Hsp90 inhibitors in hepatocellular carcinoma, Samy Mohamady, Muhammad I. Ismail, Samar M. Mogheith, Yasmeen M. Attia, and Scott D. Taylor
Eco-friendly-assessed TLC-densitometry and absorptivity coefficient based spectrophotometric methods for resolution and simultaneous analysis of two gastrointestinal acting drugs with superimposed spectra, Ekram Hany Mohamed and Christine M. El-Maraghy
A smart green spectrophotometric method for simultaneous determination of severely overlapped binary mixtures using normalized spectrum and isosbestic point as resolving tools, Ekram Hany Mohamed, Ahmed Hamza, Aya Reda, Ola Adel, and Sara Atef
Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats, Marwan Abd Elbaset Mohamed, Rehab F. Abdel-Rahman, Sawsan S. Mahmoud, Mahmoud M. Khattab, and Marwa M. Safar
Comparison Between the Pharmacokinetics Data of Ketorolac Tromethamine Wafer a Novel Drug Delivery System and Conventional Ketorolac Tromethamine Tablets to Enhance Patient Compliance Using a New LC-MS/MS Method, Dalia Abd Elaty Mostafa, Amira Mostafa Hashad, Mai F. Ragab, and Hebatallah A. Wagdy